The Possibility of Preventive and Therapeutic Use of Green Tea Catechins in Prostate Cancer

Author(s):

Vladimir S. Rogovskii*, Sergey V. Popov, Nikolai V. Sturov and Nikolai L. Shimanovskii   Pages 1223 - 1231 ( 9 )

Abstract:

<P>Background: Prostate cancer is one of the most frequent types of cancer. Despite the existence of various treatment strategies, treatment of prostate cancer still presents serious difficulties (especially in advanced stages). Polyphenols have been extensively assessed in terms of their potential use for prostate cancer treatment and prevention. Catechins are among the most well-known polyphenols in this respect. </P><P> Objective: In this review, we summarize clinical study results concerning catechin applications with regard to prostate cancer treatment and prevention. We discuss some of the main mechanisms of the anticarcinogenic action of catechins. </P><P> Conclusion: The main mechanisms of the anticarcinogenic action of catechins are subdivided into two major types: (i) direct action on cancer cells and (ii) indirect effect based on catechins’s impact on the microenvironment of cancer cells, particularly in relation to the immune system. At this level catechins might reduce tumor-associated inflammation and immune tolerance.</P>

Keywords:

Catechins, polyphenols, cancer, prostate cancer, inflammation, immunity, immune tolerance.

Affiliation:

Department of Molecular Pharmacology and Radiobiology, Pirogov Russian National Research Medical University (RNRMU), Moscow, Department of General medical practice, Medical Institute Peoples' Friendship University of Russia, Moscow, Department of General medical practice, Medical Institute Peoples' Friendship University of Russia, Moscow, Department of Molecular Pharmacology and Radiobiology, Pirogov Russian National Research Medical University (RNRMU), Moscow

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