2-Pyrazolines as Biologically Active and Fluorescent Agents, An Overview

Author(s):

Pramod Singh*, Jitendra Singh, Geeta J. Pant* and Mohan S.M. Rawat   Pages 1366 - 1385 ( 20 )

Abstract:

Nitrogen-containing five-membered heterocyclics play a vital role in pharmaceuticals as well as medicinal chemistry. Pyrazolines play a significant role among other heterocycles because of their therapeutic and pharmacological properties. 2-Pyrazolines displayed a wide variety of biological activities such as anticancer, antiepileptic, anti-aids, antimalarial, insecticidal, antitubercular, etc. and they are used as pesticides, herbicides, fungicides and also used in agrochemical research and analytical chemistry. 2-Pyrazolines are well-known brightening agents used in chemosensor. They have excellent fluorescent properties and are widely used in synthetic fibers, dyes, photography and hole transporting materials. A number of preparation methods of pyrazolines have also been investigated by several research groups. In this review, most of the synthesized and reported nitrogen-containing five-membered heterocycles including 2-pyrazolines, their pharmaceutical evaluation and structure-reactivity are discussed.

Keywords:

Biological activities, brightening agents, chalcones, fluorescence, heterocycles, 2-pyrazolines.

Affiliation:

Department of Chemistry, H.N.B.Garhwal University, (A Central University), Srinagar Garhwal, 246174 Uttarakhand, Department of Chemistry, H.N.B.Garhwal University, (A Central University), Srinagar Garhwal, 246174 Uttarakhand, Department of Chemistry, H.N.B.Garhwal University, (A Central University), Srinagar Garhwal, 246174 Uttarakhand, Department of Chemistry, H.N.B.Garhwal University, (A Central University), Srinagar Garhwal, 246174 Uttarakhand

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