Bakuchiol: A Potential Anticancer Compound from <i>Psoralea corylifolia</i> Linn

Author(s):

Bhawna Chopra, Ashwani Kumar Dhingra*, Ajmer Singh Grewal, Akash Jain, Jasmine Chaudhary and Parul Grover   Pages 989 - 998 ( 10 )

Abstract:

<p>Background: Bakuchiol is a monoterpene phenol isolated from the seeds of Psoralea corylifolia Linn. It is used traditionally in Indian and Chinese medicine and has been reported to possess extensive pharmacological potential against a variety of ailments. A recent study enumerates the anticancer potential of bakuchiol. <p> Objective: The objective of the present review study is to explore the anticancer potential of bakuchiol which provides insight into the design and develop novel molecular entities against various disorders. <p> Methods: Current prose and patents emphasizing the anticancer potential of bakuchiol have been identified and reviewed with particular emphasis on their scientific impact and novelty. An extensive literature survey was performed and compiled via the search engine, PubMed, Science Direct, and from many reputed foundations. <p> Results: The study's findings suggested and verified the anticancer potential that Psoralea and bakuchiol against a variety of cancer. Both Psoralea and bakuchiol also portrayed synergistic or potentiating effects when given in combination with other anticancer drugs or natural compounds. <p> Conclusion: Altogether, the promising anticancer potential of bakuchiol may open new probes for therapeutic invention in various types of tumors. Thus, the present review gives the erudition of bakuchiol and Psoralea as anticancer which paves the way for further work in exploring their potential.</p>

Keywords:

Bakuchiol, monoterpene, anti-cancer, derivatives, Psoralea corylifolia, pharmacological potential.

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