A Recent Advancement in Nanotechnology Approaches for the Treatment of Cervical Cancer

Author(s):

Yashoda Mariappa Hegde, Panneerselvam Theivendren*, Geetha Srinivas, Monashilpa Palanivel, Nivetha Shanmugam, Selvaraj Kunjiappan, Sivakumar Vellaichamy, Murugananthan Gopal and Senthil Rajan Dharmalingam   Pages 37 - 59 ( 23 )

Abstract:

<P>Background: Cervical cancer is one of the leading causes of female death, with a mortality rate of over 200,000 per year in developing countries. Despite a decrease in cervical cancer occurrences in developed countries over the last decade, the frequency of the disease in developing nations continues to rise at an alarming rate, particularly when it is linked to the human papillomavirus (HPV). With just a few highly invasive conventional therapies available, there is a clear need for novel treatment options such as nanotechnology-based chemotherapeutic drug delivery. <P> Methods: Traditional anticancer therapy is limited by poor drug potency, non-specificity, unwanted side effects, and the development of multiple drug resistance (MDR), leading to a decrease in long-term anticancer therapeutic efficacy. An ideal cancer therapy requires a personalized and specialized medication delivery method capable of eradicating even the last cancer cell responsible for disease recurrence. <P> Results: Nanotechnology provides effective drug delivery mechanisms, allowing it to serve both therapeutic and diagnostic purposes. Nanotechnology-based formulations are widely used to accurately target the target organ, maintain drug load bioactivity, preferentially accumulate the drug at the target location, and reduce cytotoxicity. <P> Conclusion: The key benefits of this drug delivery are that it improves pharmacological activity, solubility, and bioavailability and reduces toxicity in the target tissue by targeting ligands, allowing for new innovative treatment methods in an area that is desperately required. The goal of this review is to highlight possible research on nanotechnologybased delivery systems for cancer detection and treatment.</P>

Keywords:

Cervical cancer, human papillomavirus, nanotechnology, drug delivery, diagnosis, treatment methods.

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