Liposomal Drug Delivery and Its Potential Impact on Cancer Research

Author(s):

Sankha Bhattacharya*, Dnyanesh Saindane and Bhupendra G. Prajapati   Pages 2671 - 2683 ( 13 )

Abstract:

Liposomes are one of the most versatile drug carriers due to their functional properties, such as higher biocompatibility, the ability to encapsulate hydrophilic and hydrophobic products, and higher biodegradability. Liposomes are a better and more significant nanocarrier for cancer therapy. The key to developing a better cancer-targeted nanocarrier is the development of targeted liposomes using various approaches. Several traditional and novel liposome preparation methods are briefly discussed in this mini-review. The current state of liposome targeting, active and passive liposome targeting in cancer therapy, ligand directed targeting (antibody, aptamer, and protein/peptide-mediated targeting), and other miscellaneous approaches such as stimuli-responsive liposome-based targeting, autophagy inhibition mediated targeting, and curcumin loaded liposomal targeting are all discussed within. All of this gathered and compiled information will shed new light on liposome targeting strategies in cancer treatment and will pique the interest of aspiring researchers and academicians.

Keywords:

Liposomes, lipoplexes, aptamer drug delivery, marketed liposomal formulations, ligand-based targeting, cancer therapy.

Affiliation:

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