Recent Trends in Drug Development for the Treatment of Adenocarcinoma Breast Cancer: Thiazole, Triazole, and Thiosemicarbazone Analogues as Efficient Scaffolds

Author(s):

Cauê Benito Scarim * and Chung Man Chin   Pages 2204 - 2240 ( 37 )

Abstract:

Thiazoles, triazoles, and thiosemicarbazones function as efficient scaffolds in compounds for the treatment of several illnesses, including cancers. In this review article, we have demonstrated various studies involving these three pharmacophore classes (thiazoles, triazoles, and thiosemicarbazones) in medicinal chemistry over the last decade (2011-2021) with a focus on MCF-7 adenocarcinoma breast cancer cells. Our objective is to facilitate drug discovery of novel chemotherapeutic agents by detailing anti-proliferative compounds.

Keywords:

Thiazoles, triazoles, thiosemicarbazones, anti-proliferative, breast cancer, MCF-7.

Affiliation:

Sao Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, SP, 14800-903, Sao Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, SP, 14800-903

Graphical Abstract:

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