Anticancer Active Heterocyclic Chalcones: Recent Developments

Author(s):

Prasad Dandawate, Khursheed Ahmed, Subhash Padhye, Aamir Ahmad* and Bernhard Biersack*   Pages 558 - 566 ( 9 )

Abstract:

<P>Background: Chalcones are structurally simple compounds that are easily accessible by synthetic methods. Heterocyclic chalcones have gained the interest of scientists due to their diverse biological activities. The anti-tumor activities of heterocyclic chalcones are especially remarkable and the growing number of publications dealing with this topic warrants an up-to-date compilation. </P><P> Methods: Search for antitumor active heterocyclic chalcones was carried out using Pubmed and Scifinder as common web-based literature searching tools. Pertinent and current literature was covered from 2015/2016 to 2019. Chemical structures, biological activities and modes of action of anti-tumor active heterocyclic chalcones are summarized. </P><P> Results: Simply prepared chalcones have emerged over the last years with promising antitumor activities. Among them, there are a considerable number of tubulin polymerization inhibitors. But there are also new chalcones targeting special enzymes such as histone deacetylases or with DNA-binding properties. </P><P> Conclusion: This review provides a summary of recent heterocyclic chalcone derivatives with distinct antitumor activities.</P>

Keywords:

Chalcone, heterocycle, anticancer agents, drug design, tubulin, histone deacetylase.

Affiliation:

Interdisciplinary Science and Technology Research Academy, Abeda Inamdar Senior College, University of Pune, 2390-B, K.B. Hidayatullah Road, Pune 411001, Department of Chemistry, Abeda Inamdar Senior College, University of Pune, 2390-B, K.B. Hidayatullah Road, Pune 411001, Interdisciplinary Science and Technology Research Academy, Abeda Inamdar Senior College, University of Pune, 2390-B, K.B. Hidayatullah Road, Pune 411001, University of Alabama at Birmingham, 9th Ave South, Birmingham AL 33294, Organic Chemistry Laboratory, University of Bayreuth, Universitätsstrasse 30, 95440 Bayreuth

Graphical Abstract:

Read Full-Text article