Anticancer Perspectives on the Fungal-Derived Polyphenolic Hispolon

Author(s):

Muhammad T. Islam, Eunus S. Ali, Ishaq N. Khan, Subrata Shaw, Shaikh Jamal Uddin, Razina Rouf, Shrabanti Dev, Seyed S.S. Saravi, Niranjan Das, Swati Tripathi, Santosh U. Yele, Asish K. Das, Jamil A. Shilpi, Siddhartha K. Mishra and Mohammad S. Mubarak*   Pages 1636 - 1647 ( 12 )

Abstract:

<P>Background: Cancer is a dreadful disease causing thousands of deaths per year worldwide, which requires precision diagnostics and therapy. Although the selection of therapeutic regimens depends on the cancer type, chemotherapy remains a sustainable treatment strategy despite some of its known side-effects. To date, a number of natural products and their derivatives or analogues have been investigated as potent anticancer drugs. These drug discoveries have aimed for targeted therapy and reduced side-effects, including natural therapeutic regimens. </P><P> Objective: This review introduces a prospective fungal-derived polyphenol, Hispolon (HIS), as an anticancer agent. Accordingly, this review focuses on exploring the anticancer effect of hispolon based on information extracted from databases such as PubMed, ScienceDirect, MedLine, Web of Science, and Google Scholar. </P><P> Methods: A literature search in PubMed, ScienceDirect, MedLine, Web of Science, and Google Scholar was accomplished, using the keyword ‘Hispolon’, pairing with ‘cancer’, ‘cytotoxicity’, ‘cell cycle arrest’, ‘apoptosis’, ‘metastasis’, ‘migration’, ‘invasion’, ‘proliferation’, ‘genotoxicity’, ‘mutagenicity’, ‘drug-resistant cancer’, ‘autophagy’, and ‘estrogen receptor. </P><P> Results: Database-dependent findings from reported research works suggest that HIS can exert anticancer effects by modulating multiple molecular and biochemical pathways, including cell cycle arrest, apoptosis, autophagy, inhibition of proliferation, metastasis, migration, and invasion. Moreover, HIS inhibits the estrogenic activity and exhibits chemoprevention prospects, possibly due to its protective effects such as anticancer and anti-inflammatory mechanisms. To date, a number of HIS derivatives and analogues have been introduced for their anticancer effects in numerous cancer cell lines. </P><P> Conclusion: Data obtained from this review suggest that hispolon and some of its derivatives can be promising anticancer agents, and may become plant-based cancer chemotherapeutic leads for the development of potent anticancer drugs, alone or in combination with other chemotherapeutic agents.</P>

Keywords:

Polyphenol, hispolon, cancer, drug-resistant cells, mechanism of action, chemotherapy.

Affiliation:

Laboratory of Theoretical and Computational Biophysics, Ton Duc Thang University, Ho Chi Minh City, Gaco Pharmaceuticals and Research Laboratory, Dhaka-1000, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, 25100, Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, Pharmacy Discipline, School of Life Sciences, Khulna University, Khulna-9208, Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science & Technology University, Gopalganj, Pharmacy Discipline, School of Life Sciences, Khulna University, Khulna-9208, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MS, Netaji Subhas Mahavidyalaya, Tripura University, Udaipur, Amity Institute of Microbial Technology, Amity University, Noida - 201313, School of Pharmacy and Technology Management, SVKM’s NMIMS, Shirpur, Pharmacy Discipline, School of Life Sciences, Khulna University, Khulna-9208, Pharmacy Discipline, School of Life Sciences, Khulna University, Khulna-9208, Cancer Biology Laboratory, School of Biological Sciences (Zoology), Dr. Harisingh Gour Central University, Sagar, 470003, Department of Chemistry, The University of Jordan, Amman 11942

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