The Interaction of GLUT1 and FOXM1 Leads to a Poor Prognosis in Colorectal Cancer

Author(s):

Xiao-Yi Kuai, Zhi-Yi Lei*, Xiao-Shuang Liu and Xin-Yu Shao*   Pages 941 - 950 ( 10 )

Abstract:

<P>Background: Colorectal Cancer (CRC) is one of the most common fatal diseases with high morbidity. Alteration of glucose metabolism is one of the hallmarks in the development of CRC. Glucose Transporter 1 (GLUT1) is a key rate-limiting protein in hyperactive glucose metabolism and up-regulated in CRC, however, the underlying mechanism of the altered metabolism in CRC is still unknown. </P><P> Methods: In this study, immunohistochemical staining was used to evaluate the expression of GLUT1 and FOXM1 in 135 paired CRC and adjacent normal tissues. The association between the expression of GLUT1/FOXM1 and clinicopathological factors was determined and the correlation between GLUT1 and FOXM1 in CRC was investigated. </P><P> Results: Our results revealed that regardless of tumor location, GLUT1 and FOXM1 were overexpressed in CRC tissues, especially in patients with positive lymph node metastasis and TNM stage III-IV. Furthermore, GLUT1 showed a significantly strong link with FOXM1 in CRC tissue. </P><P> Conclusion: Overexpression of GLUT1 and FOXM1 may play critical roles in CRC leading to a poor prognosis.</P>

Keywords:

Colorectal cancer, FOXM1, GLUT1, prognosis, altered metabolism, immunohistochemical staining.

Affiliation:

Department of Gastroenterology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, Department of Radiology, The Qinghai Provincial People’s Hospital, XiNing, QingHai, Department of Colorectal Surgery, Changhai Hospital, Shanghai, Department of Gastroenterology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu

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