The Application of the Cold Atmospheric Plasma-Activated Solutions in Cancer Treatment

Author(s):

Dayun Yan*, Jonathan H. Sherman and Michael Keidar*   Pages 769 - 775 ( 7 )

Abstract:

Background: Over the past five years, the cold atmospheric plasma-activated solutions (PAS) have shown their promissing application in cancer treatment. Similar as the common direct cold plasma treatment, PAS shows a selective anti-cancer capacity in vitro and in vivo. However, different from the direct cold atmospheric plasma (CAP) treatment, PAS can be stored for a long time and can be used without dependence on a CAP device. The research on PAS is gradually becoming a hot topic in plasma medicine. </P><P> Objectives: In this review, we gave a concise but comprehensive summary on key topics about PAS including the development, current status, as well as the main conclusions about the anti-cancer mechanism achieved in past years. The approaches to make strong and stable PAS are also summarized.

Keywords:

Plasma, cold atmospheric plasma, cancer cells, cancer treatment, reactive nitrogen species, reactive oxygen species.

Affiliation:

Department of Mechanical and Aerospace Engineering, The George Washington University, Science & Engineering Hall, 800 22nd Street, NW, Room 3550, Washington, DC 20052, Neurological Surgery, The George Washington University, Foggy Bottom South Pavilion, 22nd Street, NW, 7th Floor, Washington, DC 20037, Department of Mechanical and Aerospace Engineering, The George Washington University, Science & Engineering Hall, 800 22nd Street, NW, Room 3550, Washington, DC 20052

Graphical Abstract:

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