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Coumarin Derivatives as Anticancer Agents for Lung Cancer Therapy: A Review

[ Vol. 18 , Issue. 7 ]

Author(s):

Manvendra Kumar, Ramit Singla, Jyoti Dandriyal and Vikas Jaitak*   Pages 964 - 984 ( 21 )

Abstract:


Background: The prevalence of lung cancer is 14% among the newly diagnosed cancer cases worldwide. Currently, the number of drugs that are in clinical practice is having a high prevalence of side effect and multidrug resistance. Researchers have made an attempt to expand a suitable anticancer drug that has no MDR and side effect.

Objective: Extensive exploration of Coumarin derivatives as a potent inhibitor of variety of proteins including EGFR, tyrosine kinase, ERK1/2, PI3K, HSP 90, Bax, STAT proteins, NF-κB and telomerase which have been associated with lung cancer.

Method: The recent literature was surveyed utilizing the online resources and databases including scifinder, pubchem, EMBL, scopus and google scholar.

Results: Upon analyzing the structure-activity relationship, it was found that N-aryl carboxamide, phenyl substitution at the C-3 position and 1,2,3- triazolyl, trihydroxystilbene, amino substitution at the C-4 position of the coumarin nucleus were the most effective in targeting lung cancer.

Conclusion: This review is a collaborative and extensive compilation of synthetic strategies, mechanism of action, and the structure-activity relationship thereof for the management of lung carcinoma.

Keywords:

Lung cancer, MDR, Coumarin, NSCLC, SCLC, Multidrug resistance

Affiliation:

Central University of Punjab - Centre for Pharmaceutical Sciences and Natural Products Bathinda, Punjab, Central University of Punjab - Centre for Pharmaceutical Sciences and Natural Products Bathinda, Punjab, Central University of Punjab Bathinda, Punjab, Central University of Punjab - Centre for Pharmaceutical Sciences and Natural Products Bathinda, Punjab



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