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Stereocomplexation Assisted Assembly of Poly(γ-glutamic Acid)-graft-polylactide Nano-micelles and Their Efficacy as Anticancer Drug Carrier

[ Vol. 18 , Issue. 2 ]

Author(s):

Shulin Dai, Yucheng Feng, Shuyi Li, Yuxiao Chen, Meiqing Liu, Chao Zhang*, Wei Zhang* and Yihua Yin*   Pages 302 - 311 ( 10 )

Abstract:


Background: Micelles as drug carriers are characterized by their inherent instability due to the weak physical interactions that facilitate the self-assembly of amphiphilic block copolymers. As one of the strong physical interactions, the stereocomplexation between the equal molar of enantiomeric polylactides, i.e., the poly(L-lactide) (PLLA) and poly(D-lactide) (PDLA), may be harnessed to obtain micelles with enhanced stability and drug loading capacity and consequent sustained release.

Aims/Methods: In this paper, stereocomplexed micelles gama-PGA-g-PLA micelles) were fabricated from the stereocomplexation between poly(gama-glutamic acid)-graft-PLLA gama-PGA-g-PLA) and poly(gamaglutamic acid)-graft-PDLA gama-PGA-g-PLA). These stereocomplexed micelles exhibited a lower CMC than the corresponding enantiomeric micelles.

Result: Furthermore, they showed higher drug loading content and drug loading efficiency in addition to more sustained drug release profile in vitro. In vivo imaging confirmed that the DiR-encapsulated stereocomplexed gama-PGA-g-PLA micelles can deliver anti-cancer drug to tumors with enhanced tissue penetration. Overall, gama-PGA-g-PLA micelles exhibited greater anti-cancer effects as compared with the free drug and the stereocomplexation may be a promising strategy for fabrication of anti-cancer drug carriers with significantly enhanced efficacy.

Keywords:

Poly(lactic acid), poly(γ-glutamic acid), stereocomplexation, micelle, doxorubicin, anti-cancer drug carrier.

Affiliation:

Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instruments, School of Engineering, Sun Yat-Sen University, Guangzhou, 510006, Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instruments, School of Engineering, Sun Yat-Sen University, Guangzhou, 510006, Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instruments, School of Engineering, Sun Yat-Sen University, Guangzhou, 510006, Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instruments, School of Engineering, Sun Yat-Sen University, Guangzhou, 510006, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, Hubei, 430070, Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instruments, School of Engineering, Sun Yat-Sen University, Guangzhou, 510006, Department of Outpatient, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, Hubei, 430070

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