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Synthesis and Anticancer Study of Novel 4H-Chromen Derivatives

[ Vol. 17 , Issue. 8 ]

Author(s):

Xiaolin Lu, Gaochao Dong, Ying Zheng, Chao Zhang, Yang Qiu, Tao Lua and Xiang Zhou   Pages 1070 - 1083 ( 14 )

Abstract:


Objective/Method: A series of 4H-chromen-4-one derivatives (A1-A16) have been designed and synthesized, and they were screened for BRAF kinase inhibitory activity. Furthermore, their biological activities were evaluated in vitro.

Result: Compounds A03 and A10 displayed the most potent antiproliferative activity against human osteosarcoma cell line (U2OS) and A16 displayed the most potent antiproliferative activity against human melanoma cancer cell line (A375) in vitro, which was valuable to study further.

Keywords:

4H-Chromen-4-one, anticancer activity, BRAF (V600E) kinase, design, in vitro, synthesis.

Affiliation:

Department of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiang Su, 211198, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing 210009, Department of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiang Su, 211198, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Department of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiang Su, 211198, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Department of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiang Su, 211198

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