2-Methoxy-6-Acetyl-7-Methyljuglone: A Bioactive Phytochemical with Potential Pharmacological Activities

Author(s):

Atif Ali Khan Khalil*, Asma Saleem Qazi, Abdul Nasir, Mi-Jeong Ahn, Muhammad Ajmal Shah*, Muhammad Saad Ahmad, Wasim Sajjad, Tahir Ali, Muhammad Naeem, Fawad Ali Shah, Muhammad Tufail Ahmed Khan, Muhammad Romman, Shahfiq Ur Rehman, Adnan Haider and Raishma Noor   Pages 687 - 693 ( 7 )

Abstract:

Natural products have been the focus of biomedical and pharmaceutical research to develop new therapies in recent years. 2-methoxy-6-acetyl-7-methyljuglone (2-methoxystypandrone, MAM) a natural bioactive juglone derivative, is known to have various levels of pharmacotherapeutic efficacies as an anti-inflammatory, anticancer, antioxidant, antimicrobial, and anti-HIV activities. MAM fights cancer progression by inducing apoptosis, necroptosis and deregulating signaling pathways through H2O2-induced JNK/iNOS/NO and MAPK, ERK1/2 pathways, JNK activation, and the RIP1/RIP3 complex. In this review, we summarize the pharmacological importance of MAM in the field of drug discovery. Furthermore, this review not only emphasizes the medicinal properties of MAM, but also discusses its potential efficacy in future medicinal products.

Keywords:

2-Methoxy-6-acetyl-7-methyljuglone, antioxidant, anticancer, anti-inflammatory, antibacterial, MAPK.

Affiliation:

Department of Biological Sciences, National University of Medical Sciences, Rawalpindi 46000, Department of Biological Sciences, National University of Medical Sciences, Rawalpindi 46000, Department of Molecular Science and Technology, Ajou University, Suwon 16499, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju 52828, Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine; Hotchkiss Brain Institute, Cumming School of Medicine; University of Calgary, Alberta, T2N 4Z6, Department of Biological Sciences, National University of Medical Sciences, Rawalpindi 46000, Department of Biological Sciences, National University of Medical Sciences, Rawalpindi 46000, Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine; Hotchkiss Brain Institute, Cumming School of Medicine; University of Calgary, Alberta, T2N 4Z6, Department of Biological Sciences, National University of Medical Sciences, Rawalpindi 46000, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 44000, Department of DVM, Agriculture University Peshawar, Department of Botany, University of Chitral, Chitral, Department of Rehabilitation, North West Institute of Health Sciences, Peshawar, Department of Biological Sciences, National University of Medical Sciences, Rawalpindi 46000, Department of Chemistry, Islamia College University, Peshawar

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