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Article Details


Probiotics for the Chemoprotective Role against the Toxic Effect of Cancer Chemotherapy

[ Vol. 22 , Issue. 4 ]

Author(s):

Aafrin Waziri, Charu Bharti, Mohammed Aslam, Parween Jamil, Mohd. Aamir Mirza, Md Noushad Javed, Uzma Pottoo, Amirhossein Ahmadi and Md Sabir Alam*   Pages 654 - 667 ( 14 )

Abstract:


Background: Chemo- and radiation therapy-based clinical management of different types of cancers is associated with toxicity and several side effects. Therefore, there is always an unmet need to explore agents that reduce such risk factors. Among these, natural products have attracted much attention because of their potent antioxidant and antitumor effects. In the past, some breakthrough outcomes established that various bacteria in the human intestinal gut are bearing growth-promoting attributes and suppressing the conversion of pro-carcinogens into carcinogens. Hence probiotics integrated approaches are nowadays being explored as rationalized therapeutics in the clinical management of cancer. <P> Methods: Here, published literature was explored to review chemoprotective roles of probiotics against toxic and side effects of chemotherapeutics. <P> Results: Apart from excellent anti-cancer abilities, probiotics alleviate toxicity & side effects of chemotherapeutics, with a high degree of safety and efficiency. <P> Conclusion: Preclinical and clinical evidence suggests that due to the chemoprotective roles of probiotics against side effects and toxicity of chemotherapeutics, their integration in chemotherapy would be a judicious approach.

Keywords:

Anticancer, probiotics, radiation, antioxidant, cancer, chemotherapy, pre-biotics, post-biotics, <i>Bifidobacterium, Lactobacillus</i>, gut microbiota.

Affiliation:

University School of Biotechnology, Guru Gobind Singh Indraprastha University, Delhi, School of medical and Allied Sciences, K R Mangalam University, Haryana, Faculty of Pharmacy, AL Hawash Private University, Homs, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, Faculty of Pharmacy, Jamia Hamdard, New Delhi, Faculty of Pharmacy, Jamia Hamdard, New Delhi, Department of Food Science & Technology, School of Applied Sciences & Technology, University of Kashmir, JK, Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, School of medical and Allied Sciences, K R Mangalam University, Haryana

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