Radioprotective Role of Natural Polyphenols: From Sources to Mechanisms

Author(s):

Muhammad Adnan, Azhar Rasul, Muhammad A. Shah, Ghulam Hussain, Muhammad Asrar, Ammara Riaz, Iqra Sarfraz, Arif Hussain, Khatereh Khorsandi, Ngit S. Lai and Syed M. Hussain*   Pages 30 - 39 ( 10 )

Abstract:

Abstract: The identification and development of radioprotective agents have emerged as a subject matter of research during recent years due to the growing usage of ionizing radiation in different areas of human life. Previous work on synthetic radioprotectors has achieved limited progress because of the numerous issues associated with toxicity. Compounds extracted from plants have the potential to serve as lead candidates for developing ideal radioprotectors due to their low cost, safety, and selectivity. Polyphenols are the most abundant and commonly dispersed group of biologically active molecules possessing a broad range of pharmacological activities. Polyphenols have displayed efficacy for radioprotection during various investigations and can be administered at high doses with lesser toxicity. Detoxification of free radicals, modulating inflammatory responses, DNA repair, stimulation of hematopoietic recovery, and immune functions are the main mechanisms for radiation protection with polyphenols. Epicatechin, epigallocatechin-3-gallate, apigenin, caffeic acid phenylethylester, and silibinin provide cytoprotection together with the suppression of many pro-inflammatory cytokines owing to their free radical scavenging, anti-oxidant, and anti-inflammatory properties. Curcumin, resveratrol, quercetin, gallic acid, and rutin's radioprotective properties are regulated primarily by the direct or indirect decline in cellular stress. Thus, polyphenols may serve as potential candidates for radioprotection in the near future; however, extensive investigations are still required to better understand their protection mechanisms.

Keywords:

Radioprotective compounds, polyphenols, flavonoids, ionizing radiations, antioxidants, detoxification.

Affiliation:

Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Government College University Faisalabad 38000, Neurochemical biology and Genetics Laboratory, Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Department of Photodynamic, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Institute for Research in Molecular Medicine Universiti Sains Malaysia, Pulau Pinang, Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000

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