Radioprotective Potential of Nutraceuticals and their Underlying Mechanism of Action

Author(s):

Shabnoor Iqbal, Muhammad Ajmal Shah*, Azhar Rasul, Malik Saadullah, Sobia Tabassum, Shujat Ali, Muhammad Zafar, Haji Muhammad, Md Sahab Uddin, Gaber El-Saber Batiha and Celia Vargas-De-La-Cruz   Pages 40 - 52 ( 13 )

Abstract:

Abstract: Radiations are an efficient treatment modality in cancer therapy. Besides the treatment effects of radiations, the ionizing radiations interact with biological systems and generate reactive oxygen species that interfere with the normal cellular process. Previous investigations have been conducted only on few synthetic radioprotectors, mainly owing to some limiting effects. The nutraceuticals act as efficient radioprotectors to protect the tissues from the deleterious effects of radiation. The main radioprotection mechanism of nutraceuticals is the scavenging of free radicals while other strategies involve modulation of signaling transduction pathways like MAPK (JNK, ERK1/2, ERK5, and P38), NF-kB, cytokines, and their protein regulatory gene expression. The current review is focused on the radioprotective effects of nutraceuticals including vitamin E, -C, organosulphur compounds, phenylpropanoids, and polysaccharides. These natural entities protect against radiation-induced DNA damage. The review mainly entails the antioxidant perspective and radioprotective molecular mechanism of nutraceuticals, DNA repair pathway, anti-inflammation, immunomodulatory effects and regeneration of hematopoietic cells.

Keywords:

Radioprotector, nutraceuticals, antioxidants, anticancer, natural products, chemoprevention.

Affiliation:

Department of Zoology, Faculty of Life Sciences, Government College University Faisalabad, Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Department of Zoology, Faculty of Life Sciences, Government College University Faisalabad, Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Department of Biological Sciences, International Islamic University, Islamabad, School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, Department of Plant Sciences, Quaid‐i‐Azam University, Islamabad, Department of Chemistry, Federal Urdu University of Arts, Science & Technology, Karachi, Department of Pharmacy, Southeast University, Dhaka, Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, AlBeheira, Faculty of Pharmacy and Biochemistry, Academic Department of Pharmacology, Bromatology and Toxicology, Centro Latinoamericano de Enseñanza e Investigación en Bacteriología Alimentaria (CLEIBA), Universidad Nacional Mayor de San Marcos, Lima15001

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