Xanthohumol: A Metabolite with Promising Anti-Neoplastic Potential

Author(s):

Hardeep S. Tuli*, Vaishali Aggarwal, Gaurav Parashar, Diwakar Aggarwal, Nidarshana C. Parashar, Muobarak J. Tuorkey, Mehmet Varol, Katrin Sak, Manoj Kumar and Harpal S. Buttar   Pages 418 - 432 ( 15 )

Abstract:

The overwhelming global burden of cancer has posed numerous challenges and opportunities for developing anti-cancer therapies. Phytochemicals have emerged as promising synergistic compounds with potential anti-cancer effects to supplement chemo- and immune-therapeutic regimens. Anti cancer synergistic effects have been investigated in the interaction between phytocompounds derived from flavonoids such as quercetin, apigenin, kaempferol, hesperidin, emodin, <i>etc</i>., and conventional drugs. Xanthohumol is one of the prenylated phytoflavonoid that has demonstrated key anti-cancer activities in <i>in vitro</i> (anti proliferation of cancer cell lines) and <i>in vivo</i> (animal models of xenograft tumours) studies, and has been explored from different dimensions for targeting cancer subtypes. In the last decade, xanthohumol has been investigated how it induces the anti- cancer effects at cellular and molecular levels. The different signalling cascades and targets of xanthohumol are summarized in this review. Overall, this review summarizes the current advances made in the field of natural compounds with special reference to xanthohumol and its promising anti-cancer effects to inhibit tumour progression. The present review has also discussedthe potential of xanthohumol transitioning into a leadingcandidate from nano-therapy viewpoint along with the challenges which need to be addressed for extensive preclinical and clinical anti-cancer studies.

Keywords:

Xanthohumol, apoptosis, cell cycle arrest, anti-angiogenesis, anti-metastasis, antiinflammation.

Affiliation:

Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala – 133 207, Haryana, Department of Pharmaceutical Sciences, University of Pittsburgh, PA, Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala – 133 207, Haryana, Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala – 133 207, Haryana, Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala – 133 207, Haryana, Division of Physiology, Zoology Department, Faculty of Science, Damanhour University, Damanhour, Department of Molecular Biology and Genetics, Faculty of Science, MuglaSitkiKocman University, Mugla TR48000, NGO Praeventio, Tartu 50407, Department of Chemistry, Maharishi Markandeshwar University, Sadopur, Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario

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