Theoretical Study of the Process of Passage of Glycoside Amides through the Cell Membrane of Cancer Cell

Author(s):

Vasil Tsanov* and Hristo Tsanov   Pages 1612 - 1623 ( 12 )

Abstract:

<p>Background: This article concentrates on the processes occurring in the medium around the cancer cell and the transfer of glycoside amides through their cell membrane. They are obtained by modification of natural glycoside-nitriles (cyano-glycosides). Hydrolysis of starting materials in the blood medium and associated volume around physiologically active healthy and cancer cells, based on quantum-chemical semiempirical methods, are considered. </P><P> Objective: Based on the fact that the cancer cell feeds primarily on carbohydrates, it is likely that organisms have adapted to take food containing nitrile glycosides and/or modified forms to counteract "external" bioactive activity. For their part, cancers have evolved to create conditions around their cells that eliminate their active apoptotic forms. This is far more appropriate for them than changing their entire enzyme regulation to counteract it. In this way, it protects itself and the gene sets and develops accordingly. </P><P> Methods: Pedestal is derived that closely defines the processes of hydrolysis in the blood, the transfer of a specific molecular hydrolytic form to the cancer cell membrane and with the help of time-dependent densityfunctional quantum-chemical methods, its passage and the processes of re-hydrolysis within the cell itself, to bioactive forms causing chemical apoptosis of the cell-independent of its non-genetic set, which seeks to counteract the process. </P><P> Results: Used in oncology, it could turn a cancer from a lethal to a chronic disease (such as diabetes). The causative agent and conditions for the development of the disease are not eliminated, but the amount of cancer cells could be kept low for a long time (even a lifetime). </P><P> Conclusion: The amide derivatives of nitrile glycosides exhibit anticancer activity; the cancer cell probably seeks to displace hydrolysis of these derivatives in a direction that would not pass through its cell membrane and the amide-carboxyl derivatives of nitrile glycosides could deliver extremely toxic compounds within the cancer cell itself and thus block and/or permanently damage its normal physiology.</p>

Keywords:

Glycoside amides, cancer cell membrane, hydrolysis, PM7, TD-DFT, apoptosis.

Affiliation:

Academy of Ministry of Interior, Fire Safety and Civil Protection, Sofia, Academy of Ministry of Interior, Fire Safety and Civil Protection, Sofia

Graphical Abstract:

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