Association of Hippo Signalling Pathway with Epigenetic Changes in Cancer Cells and Therapeutic Approaches: A Review

Author(s):

Roza Motavalli, Faroogh Marofi, Maryam Nasimi, Mehdi Yousefi and Farhad M. Khiavi*   Pages 1520 - 1528 ( 9 )

Abstract:

Hippo signalling pathway that is evolutionarily conserved affects diver’s pathology and physiology processes, including tissue repair, wound healing, tissue size and tissue regeneration. Epigenetic changes are post-translational modifications in DNA proteins and histones. Epigenetic changes including histone acetylation and deacetylation, miRNAs dysregulation, and aberrant DNA methylation, inflammatory genes actives abnormal in Hippo signaling pathway. Using some treatments, including Histone Deacetylases (HDACs), herbal composition, siRNAs and long non-coding RNA (lncRNA) for suppressing cancer cells by targeting Hippo pathways, may open new views in cancer target therapy fields. The aim of this review study is firstly to demonstrate the importance of Hippo signalling and its association with epigenetic changes in cancer and then to demonstrate progress in targeting Hippo signalling in cancer therapy.

Keywords:

Hippo signalling, cancer cell, tissue regeneration, HDACs, lncRNA, DNA methylation.

Affiliation:

Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Department of Hematology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Department of Dermatology, Tehran University of Medical Sciences, Tehran, Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Department of Virology, Pasteur Institute of Iran, Tehran

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