Fluorinated-NHC Transition Metal Complexes: Leading Characters as Potential Anticancer Metallodrugs

Author(s):

Ernesto Rufino-Felipe, Raúl Colorado-Peralta, Viviana Reyes-Márquez , Hugo Valdés and David Morales-Morales*   Pages 938 - 948 ( 11 )

Abstract:

In the last 20 years, N-Heterocyclic Carbene (NHC) ligands have been ubiquitous in biological and medicinal chemistry. Part of their success lies in the tremendous number of topologies that can be synthesized and thus finely tuned that have been described so far. This is particularly true in the case of those derivatives, including fluorine or fluorinated fragments on their NHC moieties, gaining much attention due to their enhanced biological properties and turning them into excellent candidates for the development of novel metallodrugs. Thus, this review summarizes the development that fluorinated-NHC transition metal complexes have had and their impact on cancer treatment.

Keywords:

Cytotoxicity, fluorinated complexes, NHC complexes, cancer, N-heterocyclic Carbene (NHC), fluorine, metallodrugs.

Affiliation:

Instituto de Quimica, Universidad Nacional Autonoma de Mexico, Circuito Exterior, Ciudad Universitaria, Coyoacan, Ciudad de Mexico, C.P. 04510, Facultad de Ciencias Quimicas, Universidad Veracruzana, Oriente 6 1009, Col. Rafael Alvarado, C.P. 94340, Orizaba, Veracruz, Departamento de Ciencias Quimico-Biologicas, Universidad de Sonora, Luis Encinas y Rosales s/n. CP 83000. Hermosillo, Sonora, Instituto de Quimica, Universidad Nacional Autonoma de Mexico, Circuito Exterior, Ciudad Universitaria, Coyoacan, Ciudad de Mexico, C.P. 04510, Instituto de Quimica, Universidad Nacional Autonoma de Mexico, Circuito Exterior, Ciudad Universitaria, Coyoacan, Ciudad de Mexico, C.P. 04510

Graphical Abstract:

Read Full-Text article