Recent Progress in the Development of Quinoline Derivatives for the Exploitation of Anti-Cancer Agents

Author(s):

Ruo-Jun Man, Nasreen Jeelani, Chongchen Zhou* and Yu-Shun Yang*   Pages 825 - 838 ( 14 )

Abstract:

<P>Background: Along with the progress in medicine and therapies, the exploitation of anti-cancer agents focused more on the vital signaling pathways and key biological macromolecules. With rational design and advanced synthesis, quinoline derivatives have been utilized frequently in medicinal chemistry, especially in developing anti-cancer drugs or candidates. </P><P> Methods: Using DOI searching, articles published before 2020 all over the world have been reviewed as comprehensively as possible. </P><P> Results: In this review, we selected the representative quinoline derivate drugs in market or clinical trials, classified them into five major categories with detailed targets according to their main mechanisms, discussed the relationship within the same mechanism, and generated a summative discussion with prospective expectations. For each mechanism, the introduction of the target was presented, with the typical examples of quinoline derivate drugs. </P><P> Conclusion: This review has highlighted the quinoline drugs or candidates, suited them into corresponding targets in their pathways, summarized and discussed. We hope that this review may help the researchers who are interested in discovering quinoline derivate anti-cancer agents obtain considerable understanding of this specific topic. Through the flourishing period and the vigorous strategies in clinical trials, quinoline drugs would be potential but facing new challenges in the future.</P>

Keywords:

Anti-cancer agents, quinoline derivatives, marketed drugs, clinical trials, molecular targets, major mechanisms.

Affiliation:

College of Chemistry and Chemical Engineering, Guangxi University for Nationalities, Nanning, Institute of Chemistry and BioMedical Sciences, School of Life Sciences, Nanjing University, Nanjing 210023, Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou University, Zhengzhou, 450018, Institute of Chemistry and BioMedical Sciences, School of Life Sciences, Nanjing University, Nanjing 210023

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